General paresis is an impairment of mental function caused by damage to the brain from untreated syphilis.
Causes, incidence, and risk factors:
General paresis is one form of neurosyphilis. Today it is very rare.
The syphilis infection damages the nerves of the brain. This damage causes:
Abnormal mental function including hallucinations and false ideas (delusions)
Brief, sharp, "lightning" pains that occur with tabes dorsalis
Decreased mental function
Eye changes and abnormal pupil response
Mood changes
Overactive reflexes
Personality changes
Speech changes
General paresis usually begins about 15-20 years after the syphilis infection. Risks include syphilis infection and infection with other sexually transmitted diseases, such as gonorrhea (which may hide symptoms of syphilis infection).
Syphilis infections are passed through sexual contact with an infected person, but may also be transmitted by non-sexual contact.
Luc Jasmin, MD, PhD, Departments of Anatomy & Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
References
Moore DP, Jefferson JW. Handbook of Medical Psychiatry. 2nd ed. St. Louis, Mo: Mosby; 2004:404-406.
Goetz, CG. Textbook of Clinical Neurology. 2nd ed. St. Louis, Mo: WB Saunders; 2003: 931-933.
