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Peripheral artery disease - Overview

Alternative Names

Blockage of leg arteries; Claudication; Intermittent claudication; Vaso-occlusive disease of the legs; Arterial insufficiency of the legs; Recurrent leg pain and cramping; Calf pain with exercise

Definition of Peripheral artery disease:

Peripheral artery disease (PAD) is a problem with blood flow in the arteries, usually the legs. Poor circulation and blockage of blood in the leg arteries produces an aching, tired, and sometimes burning pain in the legs.

The pain from PAD is brought on by exercise, and relieved by rest. The limping that occurs from the leg pain is called claudication.

Considerations:

This condition may occur in both legs, and the symptoms often get worse over time. However, some people complain only of weakness in the legs when walking, or a feeling of "tiredness" in the buttocks. Impotence is an occasional complaint in men. Pain at rest is uncommon.

Common Causes:

This condition is due to atherosclerosis or peripheral vascular disease. Narrowed or blocked arteries can occur anywhere in the body. If they occur in the heart, a person may have chest pain (angina) or even a heart attack. If arteries are blocked or narrowed in the neck or the brain, a person may have a stroke.

Intermittent claudication is when the blockage occurs in the legs, most commonly in the calf or the foot. It occurs only at certain times, such as after a period of walking, and is relieved by rest.

Atherosclerosis can occur for many reasons such as smoking, diabetes, and high cholesterol.

  • Reviewed last on: 5/12/2008
  • Larry A. Weinrauch, MD, Assistant Professor of Medicine, Harvard Medical School, and Private practice specializing in Cardiovascular Disease, Watertown, MA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Creager MA, Libby P. Peripheral arterial disease. In: Libby P, Bonow RO, Mann DL, Zipes DP, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 8th ed. St. Louis, Mo: WB Saunders; 2007: chap. 57.